Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae

Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae

ABSTRACT Polymyxins are last-line antibiotics employed against multidrug-resistant (MDR) Klebsiella pneumoniae. Worryingly, polymyxin resistance is rapidly on the rise globally. Polymyxins initially target lipid A of lipopolysaccharides (LPSs) in the cell outer membrane (OM), causing disorganization...

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Bibliographic Details
Main Authors: Jing Lu, Meiling Han, Heidi H. Yu, Phillip J. Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
Klebsiella pneumoniae
polymyxin
lipid A modification
metabolomics
lipidomics
phoQ
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00852-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00852-23

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