Unraveling the mechanisms of NK cell dysfunction in aging and Alzheimer’s disease: insights from GWAS and single-cell transcriptomics

Unraveling the mechanisms of NK cell dysfunction in aging and Alzheimer’s disease: insights from GWAS and single-cell transcriptomics

BackgroundAging is an important factor in the development of Alzheimer’s disease (AD). The senescent cells can be recognized and removed by NK cells. However, NK cell function is gradually inactivated with age. Therefore, this study used senescence as an entry point to investigate how NK cells affec...

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Bibliographic Details
Main Authors: Jinwei Li, Yang Zhang, Yanwei You, Zhiwei Huang, Liya Wu, Cong Liang, Baohui Weng, Liya Pan, Yan Huang, Yushen Huang, Mengqi Yang, Mengting Lu, Rui Li, Xianlei Yan, Quan Liu, Shan Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
AD
aging
ScRNA-seq
Mendelian randomization
NHANES
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360687/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360687/full

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