A comprehensive evaluation in clinic and physiologically‐based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450–mediated drug–drug interaction potential for pomotrelvir

A comprehensive evaluation in clinic and physiologically‐based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450–mediated drug–drug interaction potential for pomotrelvir

Abstract Pomotrelvir is a new chemical entity and potent direct‐acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)–mediated drug–drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, starting with in vitro assays followed...

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Bibliographic Details
Main Authors: Ziping Yang, Nathalie Rioux, Ludwig Vincent, Hannah M. Jones, David Cha, Andrew Plummer, David Wilfret, Brian P. Kearney
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13034

Internet

https://doi.org/10.1002/psp4.13034

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