A comprehensive evaluation in clinic and physiologically‐based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450–mediated drug–drug interaction potential for pomotrelvir
Abstract Pomotrelvir is a new chemical entity and potent direct‐acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)–mediated drug–drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, starting with in vitro assays followed...
| Main Authors: | , , , , , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Wiley
2023-10-01
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| סדרה: | CPT: Pharmacometrics & Systems Pharmacology |
| גישה מקוונת: | https://doi.org/10.1002/psp4.13034 |