Zn2+-dependent functional switching of ERp18, an ER-resident thioredoxin-like protein

Zn2+-dependent functional switching of ERp18, an ER-resident thioredoxin-like protein

Summary: ERp18 is an endoplasmic reticulum (ER)-resident thioredoxin (Trx) family protein, similar to cytosolic Trx1. The Trx-like domain occupies a major portion of the whole ERp18 structure, which is postulated to be an ER paralog of cytosolic Trx1. Here, we elucidate that zinc ion (Zn2+) binds ER...

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Bibliographic Details
Main Authors: Chika Tsutsumi, Kaiku Uegaki, Riyuji Yamashita, Ryo Ushioda, Kazuhiro Nagata
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472400010X

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http://www.sciencedirect.com/science/article/pii/S221112472400010X

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