Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study

Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study

IntroductionThe polyspecific intrathecal immune response (PSIIR), aka MRZ reaction (M = measles, R = rubella, Z = zoster, optionally Herpes simplex virus, HSV) is defined as intrathecal immunoglobulin synthesis (IIS) for two or more unrelated viruses. Although an established cerebrospinal fluid (CSF...

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Bibliographic Details
Main Authors: Felix Brauchle, Daniel Rapp, Makbule Senel, André Huss, Jens Dreyhaupt, Veronika Klose, Marie Süße, Klarissa Hanja Stürner, Frank Leypoldt, Hayrettin Tumani, Jan Lewerenz
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neurology
Subjects:
polyspecific intrathecal immune response
MRZ reaction
multiple sclerosis
neuroinflammation
autoimmue disease
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1193015/full

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https://www.frontiersin.org/articles/10.3389/fneur.2023.1193015/full

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