Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study

Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study

IntroductionThe polyspecific intrathecal immune response (PSIIR), aka MRZ reaction (M = measles, R = rubella, Z = zoster, optionally Herpes simplex virus, HSV) is defined as intrathecal immunoglobulin synthesis (IIS) for two or more unrelated viruses. Although an established cerebrospinal fluid (CSF...

Full description

Bibliographic Details
Main Authors:	Felix Brauchle, Daniel Rapp, Makbule Senel, André Huss, Jens Dreyhaupt, Veronika Klose, Marie Süße, Klarissa Hanja Stürner, Frank Leypoldt, Hayrettin Tumani, Jan Lewerenz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Neurology
Subjects:	polyspecific intrathecal immune response MRZ reaction multiple sclerosis neuroinflammation autoimmue disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2023.1193015/full

Similar Items

Diagnostic significance of intrathecally synthesized immunoglobulins against neurotropic viruses (MRZ-reaction) in diagnosis of multiple sclerosis
by: A. N. Moshnikova, et al.
Published: (2020-02-01)

Prediction of polyspecificity from antibody sequence data by machine learning
by: Szabolcs Éliás, et al.
Published: (2024-04-01)

Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens
by: Valentin Quiniou, et al.
Published: (2023-03-01)

The Diagnostic Significance of Intrathecal Synthesis of Antibodies Against Measles, Rubella, and Varicella Zoster Viruses in the Differential Diagnosis of Demyelinating Diseases of the Central Nervous System
by: Anna N. Moshnikova, et al.
Published: (2020-06-01)

Effect of Hydatid Cyst Antigens Polyspecific Antisera on Breast Cancer Cells (4T1) Growth in Cell Culture Medium
by: Hossein Yousofi Darani, et al.
Published: (2022-01-01)

Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity
by: Tatsushi Ishimoto, et al.
Published: (2024-03-01)

The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics
by: Diana M. Norden, et al.
Published: (2024-12-01)

Intrathecal ketorolac enhances intrathecal morphine analgesia following total knee arthroplasty
by: Gabriela R Lauretti, et al.
Published: (2013-01-01)

Comparative characteristics of the effectiveness of spinal anesthesia with intrathecal administration of bupivacaine and its combination with adjuvants
by: Ye.E. Shchegolkov
Published: (2024-03-01)

A comparative study of intrathecal ketamine as an additive to 0.5% hyperbaric bupivacaine for intrathecal anaesthesia
by: N. Hemanth, et al.
Published: (2013-10-01)

Thoracic spinal anesthesia with intrathecal sedation for lower back surgery: a retrospective cohort study
by: Nikolay Boykov, et al.
Published: (2024-04-01)

Comparative efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine in patients undergoing lower abdominal surgical procedures
by: Prasenjit Adhikari, et al.
Published: (2020-01-01)

Neurostimulation leads, intrathecal catheters and anchoring devices evolution
by: Laura Demartini, et al.
Published: (2015-03-01)

Accidental intrathecal methotrexate overdose
by: Emel Özyürek, et al.
Published: (2011-08-01)

Inadvertent intrathecal injection of labetalol
by: S Verma, et al.
Published: (2016-01-01)

Comparative characteristics of the effectiveness of spinal anesthesia based on bupivacaine in combination with different intrathecal doses of dexmedetomidine
by: E.E. Shchegolkov, et al.
Published: (2024-04-01)

Tick-Borne Encephalitis: A Differential Pattern of Intrathecal Humoral Immune Response and Inflammatory Cell Composition Compared with Other Viral CNS Infections
by: Makbule Senel, et al.
Published: (2020-09-01)

Effects of intrathecal and intravenous dexamethasone on complications associated with intrathecal morphine after cesarean section: A comparative study
by: Alieh Zamani Kiasari, et al.
Published: (2022-01-01)

Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies
by: Karen Robinson
Published: (2015-03-01)

CSF oligoclonal IgG bands are not associated with ALS progression and prognosis
by: Veronika Klose, et al.
Published: (2023-05-01)

Evaluation of the neurotoxicity of intrathecal dexmedetomidine on rat spinal cord (electromicroscopic observations)
by: Dilek Ozdamar, et al.
Published: (2018-01-01)

Management of spasticity with intrathecal phenol injections: The past and the present
by: Fahim Anwar, et al.
Published: (2019-01-01)

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
by: Kavi Ratanabanangkoon
Published: (2023-08-01)

Practical aspects of the use of intrathecal chemotherapy
by: Raquel Olmos-Jiménez, et al.
Published: (2017-01-01)

EFFECTS OF INTRATHECAL BUPIVACAINE WITH NORMAL SALINE VERSUS BUPIVACAINE WITH FENTANYL IN PATIENTS UNDERGOING SURGERY
by: Jigna R Shah, et al.
Published: (2016-03-01)

Use of Intrathecal and Intravenous Clonidine in A Case of Severe Tetanus with Acute Renal Failure
by: Alok Kumar, et al.
Published: (2009-01-01)

Inadvertent intrathecal drug injection while treating low back pain: a case report and review of the literature
by: Alessandro Ferrieri, et al.
Published: (2023-02-01)

Unmasking Late Neurological Recovery through Reduced Intrathecal Baclofen
by: Chittaranjan P. Patel, et al.
Published: (2024-04-01)

Anti-TBE Intrathecal Synthesis as a Prediction Marker in TBE Patients
by: Agnieszka Siemieniako-Werszko, et al.
Published: (2022-03-01)

A case of priapism following intrathecal morphine injection in a dog.
by: elena lardone, et al.
Published: (2022-10-01)

Dexmedetomidine versus midazolam as adjuvants to intrathecal bupivacaine: A clinical comparison
by: Usha Shukla, et al.
Published: (2016-01-01)

Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications
by: Menéndez-González Manuel, et al.
Published: (2023-02-01)

Analgesic efficacy of low-dose intrathecal neostigmine in combination with fentanyl and bupivacaine for total knee replacement surgery
by: Amit Jain, et al.
Published: (2012-01-01)

Worsening spasticity due to catheter breakage during intrathecal baclofen therapy: a case report
by: Yasutaka Takagi, et al.
Published: (2025-01-01)

Comparison of intrathecal bupivacaine with different doses of clonidine for spinal anesthesia in adults: A systematic review
by: Sangeetha Dattatri, et al.
Published: (2023-01-01)

Height-adjusted dose of intrathecal bupivacaine on surgical anesthesia for the cesarean section
by: Noyomi Saring, et al.
Published: (2023-01-01)

Accidental High-dose Intrathecal Treatment: Late Results of a Patient
by: Tiraje Celkan, et al.
Published: (2020-02-01)

Effect of intravenous versus intrathecal dexmedetomidine on the characteristic of spinal anesthesia in patients undergoing infra umbilical surgeries
by: Pradeep Kumar, et al.
Published: (2020-01-01)

A comparative evaluation of intrathecal bupivacaine alone, sufentanil or butorphanol in combination with bupivacaine for endoscopic urological surgery
by: Manpreet Kaur, et al.
Published: (2011-01-01)

Premedication for intrathecal anesthesia in dogs: xylazine versus propofol
by: Sadık YAYLA, et al.
Published: (2020-12-01)