Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes
Abstract Background Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, there was conflicting evidence about the association between NFE2L2 mut...
| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
BMC
2023-10-01
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| Серии: | Cancer Cell International |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1186/s12935-023-03056-9 |