Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure

Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure

Clinical and cognitive progression in alpha-synucleinopathies is highly heterogeneous. While some patients remain stable over long periods of time, other suffer early dementia or fast motor deterioration. Sleep disturbances and nocturnal blood pressure abnormalities have been identified as independe...

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Bibliographic Details
Main Authors: Mariateresa Buongiorno, Clara Marzal, Manel Fernandez, Natalia Cullell, Lorena de Mena, Gonzalo Sánchez-Benavides, Alejandro de la Sierra, Jerzy Krupinski, Yaroslau Compta
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
alpha-synucleinopathies
sleep disturbances
glymphatic system
cognitive decline
Parkinson’s disease
multisystem atrophy
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1251755/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1251755/full

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