Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC)

Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC)

Abstract Background Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as high penetrance genes of this syndrome. The identification of BRCA1/2 genetic alterations before cancer development, grant p...

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Bibliographic Details
Main Authors: Fatima Zahra El Ansari, Farah Jouali, Nabila Marchoudi, Mohcine Mechita Bennani, Naima Nourouti Ghailani, Amina Barakat, Jamal Fekkak
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
Hereditary breast and ovarian cancer
BRCA1
BRCA 2
Online Access:http://link.springer.com/article/10.1186/s12885-020-07250-0

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http://link.springer.com/article/10.1186/s12885-020-07250-0

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