Redirection of epithelial immune responses by short chain fatty acids through inhibition of histone deacetylases

Redirection of epithelial immune responses by short chain fatty acids through inhibition of histone deacetylases

Short-Chain Fatty Acids (SCFAs) are products of microbial fermentation that are important for intestinal epithelial health. Here we describe that SCFAs have rapid and reversible effects on Toll-like receptor (TLR) responses in epithelial cells. Incubation of HEK293 or HeLa epithelial cells with the...

Full description

Bibliographic Details
Main Authors: May Young eLin, Marcel Robert de Zoete, Jos P.M. van Putten, Karin eStrijbis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Flagellin
Toll-Like Receptors
NF-κB
histone acetylation
Butyrate
HDAC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00554/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00554/full

Similar Items