Identification of Spiro-Fused Pyrrolo[3,4-<i>a</i>]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation

Identification of Spiro-Fused Pyrrolo[3,4-<i>a</i>]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation

A series of heterocyclic compounds containing a spiro-fused pyrrolo[3,4-<i>a</i>]pyrrolizine and tryptanthrin framework have been synthesized and studied as potential antitumor agents. Cytotoxicity of products was screened against human erythroleukemia (K562) and human cervical carcinoma...

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Bibliographic Details
Main Authors: Diana K. Latypova, Stanislav V. Shmakov, Sofya A. Pechkovskaya, Alexander S. Filatov, Alexander V. Stepakov, Nickolay A. Knyazev, Vitali M. Boitsov
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
one-pot synthesis
1,3-dipolar cycloaddition
tryptanthrin-derived azomethine ylide
pyrrolo[3,4-<i>a</i>]pyrrolizine
tumor cells
antiproliferative activity
Online Access:https://www.mdpi.com/1422-0067/22/21/11997

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https://www.mdpi.com/1422-0067/22/21/11997

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