Evolution of Bacterial Persistence to Antibiotics during a 50,000-Generation Experiment in an Antibiotic-Free Environment

Evolution of Bacterial Persistence to Antibiotics during a 50,000-Generation Experiment in an Antibiotic-Free Environment

Failure of antibiotic therapies causes > 700,000 deaths yearly and involves both bacterial resistance and persistence. Persistence results in the relapse of infections by producing a tiny fraction of pathogen survivors that stay dormant during antibiotic exposure. From an evolutionary perspective...

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Bibliographic Details
Main Authors: Hugo Mathé-Hubert, Rafika Amia, Mikaël Martin, Joël Gaffé, Dominique Schneider
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antibiotics
Subjects:
antibiotic persistence
evolution
<i>Escherichia coli</i>
beta-lactam
ampicillin
fluoroquinolones
Online Access:https://www.mdpi.com/2079-6382/11/4/451

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https://www.mdpi.com/2079-6382/11/4/451

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