Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice

Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice

<i>Background and Objectives</i>: The antidiabetic agent metformin is known to activate AMP-activated protein kinase (AMPK) in various tissues. Because AMPK can modulate intracellular circadian clocks through regulating the stability of clock components, a single dose of metformin has be...

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Bibliographic Details
Main Authors: Nazmul Hasan, Koki Sugimoto, Koki Yamada, Jun-ichi Morishige, Kentaro Ushijima, Akio Fujimura, Naoto Nagata, Hitoshi Ando
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Medicina
Subjects:
metformin
circadian rhythm
clock genes
type 2 diabetes
liver
Online Access:https://www.mdpi.com/1648-9144/58/2/293

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https://www.mdpi.com/1648-9144/58/2/293

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