Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens

Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens

Abstract Purpose To evaluate a new class of blood-based biomarkers, anti-frameshift peptide antibodies, for predicting both tumor responses and adverse immune events to immune checkpoint inhibitor (ICI) therapies in advanced lung cancer patients. Experimental design Serum samples were obtained from...

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Bibliographic Details
Main Authors: Luhui Shen, Justin R. Brown, Stephen Albert Johnston, Mehmet Altan, Kathryn F. Sykes
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Checkpoint inhibitors
Immune-related adverse events
Frameshift neoantigens
Peptide microarrays
Predictive diagnostic
Lung cancer
Online Access:https://doi.org/10.1186/s12967-023-04172-w

Internet

https://doi.org/10.1186/s12967-023-04172-w

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