Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
The role of biophysical properties of protein condensates in regulating gene expression and tumorigenesis remains unclear. We recently discovered that A-kinase anchoring protein 8 (AKAP8, also known as AKAP95), a RNA splicing regulator, supports tumorigenesis by forming liquid-like condensates, and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1819753 |
| Summary: | The role of biophysical properties of protein condensates in regulating gene expression and tumorigenesis remains unclear. We recently discovered that A-kinase anchoring protein 8 (AKAP8, also known as AKAP95), a RNA splicing regulator, supports tumorigenesis by forming liquid-like condensates, and that perturbing the biophysical properties of the condensates impairs its activity in regulating splicing and tumorigenesis. |
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| ISSN: | 2372-3556 |