Platelet SR-PSOX/CXCL16–CXCR6 Axis Influences Thrombotic Propensity and Prognosis in Coronary Artery Disease

Platelet SR-PSOX/CXCL16–CXCR6 Axis Influences Thrombotic Propensity and Prognosis in Coronary Artery Disease

Platelets express the transmembrane chemokine SR-PSOX/CXCL16, proteolytic cleavage of which generates the sCXCL16 soluble-(s) chemokine. The sCXCL16 engages CXCR6 on platelets to synergistically propagate degranulation, aggregation and thrombotic response. Currently, we have investigated the pro-thr...

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Bibliographic Details
Main Authors: Tianyun Guan, Frederic Emschermann, Christoph Schories, Patrick Groga-Bada, Peter Martus, Oliver Borst, Meinrad Gawaz, Tobias Geisler, Dominik Rath, Madhumita Chatterjee
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
platelet
CXCL16
CXCR6
coronary artery disease
prognosis
Online Access:https://www.mdpi.com/1422-0067/23/19/11066

Internet

https://www.mdpi.com/1422-0067/23/19/11066

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