Differential Modulation of the Voltage-Gated Na+ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14

Differential Modulation of the Voltage-Gated Na+ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14

The voltage-gated Na+ (Nav) channel is a primary molecular determinant of the initiation and propagation of the action potential. Despite the central role of the pore-forming α subunit in conferring this functionality, protein:protein interactions (PPI) between the α subunit and auxiliary proteins a...

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Bibliographic Details
Main Authors: Aditya K. Singh, Nolan M. Dvorak, Cynthia M. Tapia, Angela Mosebarger, Syed R. Ali, Zaniqua Bullock, Haiying Chen, Jia Zhou, Fernanda Laezza
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
voltage-gated sodium channels
protein-protein interactions
intracellular fibroblast growth factors
split-luciferase complementation assays
patch-clamp electrophysiology
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.742903/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.742903/full

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