Differential Modulation of the Voltage-Gated Na+ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14

Differential Modulation of the Voltage-Gated Na+ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14

The voltage-gated Na+ (Nav) channel is a primary molecular determinant of the initiation and propagation of the action potential. Despite the central role of the pore-forming α subunit in conferring this functionality, protein:protein interactions (PPI) between the α subunit and auxiliary proteins a...

Full description

Bibliographic Details
Main Authors:	Aditya K. Singh, Nolan M. Dvorak, Cynthia M. Tapia, Angela Mosebarger, Syed R. Ali, Zaniqua Bullock, Haiying Chen, Jia Zhou, Fernanda Laezza
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Molecular Biosciences
Subjects:	voltage-gated sodium channels protein-protein interactions intracellular fibroblast growth factors split-luciferase complementation assays patch-clamp electrophysiology
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.742903/full

Similar Items

Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na<sup>+</sup> Channel 1.2 Macromolecular Complex
by: Nolan M. Dvorak, et al.
Published: (2021-11-01)

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na<sup>+</sup> Channel 1.6 Enables Isoform-Selective Modulation
by: Nolan M. Dvorak, et al.
Published: (2021-12-01)

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics
by: Nolan M. Dvorak, et al.
Published: (2020-07-01)

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
by: Peter R Strege, et al.
Published: (2023-03-01)

Patch-clamp analysis : advanced techniques /
by: Walz, Wolfgang
Published: (2007)

Block of Voltage-Gated Sodium Channels by Aripiprazole in a State-Dependent Manner
by: Karl Josef Föhr, et al.
Published: (2022-10-01)

Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I<sub>Na</sub> by Lamotrigine; A Potential for Acquired Arrythmias
by: Juan Antonio Contreras Vite, et al.
Published: (2022-09-01)

Lights, Camera, Interaction: Studying Protein–Protein Interactions of the ER Protein Translocase in Living Cells
by: Mark Sicking, et al.
Published: (2021-09-01)

Inhibition of the Akt/PKB Kinase Increases Na<sub>v</sub>1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons
by: Mate Marosi, et al.
Published: (2022-02-01)

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family
by: Rajnish Ranjan, et al.
Published: (2019-08-01)

The molecular pharmacology and modulation of the proton-activated chloride channel PAC
by: Pearson, CL
Published: (2023)

Alterations of the Hippocampal Networks in Valproic Acid-Induced Rat Autism Model
by: Veronika Bódi, et al.
Published: (2022-02-01)

Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes
by: Feng Cao, et al.
Published: (2017-05-01)

Functional Voltage-Gated Sodium Channels Are Present in the Human B Cell Membrane
by: Adam Feher, et al.
Published: (2022-04-01)

Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of Streptococcus mutans
by: Hua Qin, et al.
Published: (2024-02-01)

PKD Phosphorylation as Novel Pathway of KV11.1 Regulation
by: Annette Buur Steffensen, et al.
Published: (2018-06-01)

Voltage- and temperature-dependent allosteric modulation of alpha7 nicotinic receptors by PNU120596
by: Fabrio eSitzia, et al.
Published: (2011-12-01)

The Function of Ion Channels and Membrane Potential in Red Blood Cells: Toward a Systematic Analysis of the Erythroid Channelome
by: Marieke von Lindern, et al.
Published: (2022-02-01)

A transcriptomic and electrophysiological characterisation of the rat stellate ganglia in health and disease
by: Davis, H
Published: (2021)

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels
by: Carol J. Milligan, et al.
Published: (2023-02-01)

A Split-Luciferase Reporter Recognizing GFP and mCherry Tags to Facilitate Studies of Protein–Protein Interactions
by: Mehdi Moustaqil, et al.
Published: (2017-12-01)

Oxytocin Modifies the Excitability and the Action Potential Shape of the Hippocampal CA1 GABAergic Interneurons
by: Antonio Nicolas Castagno, et al.
Published: (2024-02-01)

Serum-deprived differentiated neuroblastoma F-11 cells express functional dorsal root ganglion neuron properties
by: Valentina Pastori, et al.
Published: (2019-10-01)

Studying Synaptic Connectivity and Strength with Optogenetics and Patch-Clamp Electrophysiology
by: Louisa E. Linders, et al.
Published: (2022-10-01)

From squid giant axon to automated patch-clamp: electrophysiology in venom and antivenom research
by: Shirin Ahmadi, et al.
Published: (2023-08-01)

Acidification of rat TRPV1 alters the kinetics of capsaicin responses
by: Faltynek Connie R, et al.
Published: (2005-09-01)

Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons
by: Gholamhossein Meftahi, et al.
Published: (2015-10-01)

Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias
by: Polina Petkova-Kirova, et al.
Published: (2019-04-01)

A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes
by: Carina Höring, et al.
Published: (2020-11-01)

Computational Screening of the Natural Product Osthole and Its Derivates for Anti-Inflammatory Activity
by: Angela Mosebarger, et al.
Published: (2022-03-01)

Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors
by: Ulrike Breitinger, et al.
Published: (2021-07-01)

A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation
by: Amin Tashakor, et al.
Published: (2019-07-01)

Dual-Color Bioluminescence Analysis for Quantitatively Monitoring G-Protein-Coupled Receptor and β-Arrestin Interactions
by: Naomi Misawa, et al.
Published: (2011-02-01)

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter
by: Vivek Garg, et al.
Published: (2021-08-01)

Electrophysiological properties of layer 2/3 pyramidal neurons in the primary visual cortex of a retinitis pigmentosa mouse model (rd10)
by: Claas Halfmann, et al.
Published: (2023-09-01)

Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2
by: Ulrike Breitinger, et al.
Published: (2023-07-01)

Advancing Luciferase-Based Antibody Immunoassays to Next-Generation Mix and Read Testing
by: Peter D. Burbelo, et al.
Published: (2023-02-01)

Alternative forms of selectivity filters and turrets, and the patterning of cysteines in extended loops provide clues to a unique extracellular domain within eukaryotic voltage-gated sodium, calcium, and NALCN channels
by: Robert F. Stephens, et al.
Published: (2015-05-01)

Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions
by: Meye Bloothooft, et al.
Published: (2024-01-01)

Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex
by: Viktor Szegedi, et al.
Published: (2020-01-01)