Structure-based pharmacological screening, molecular docking and dynamic simulation reveals Dexketoprofen as a repurposable drug against Alzheimer's disease

Structure-based pharmacological screening, molecular docking and dynamic simulation reveals Dexketoprofen as a repurposable drug against Alzheimer's disease

Alzheimer's disease (AD) is a progressive, irreversible, neurodegenerative disease that has a profound impact on memory, reasoning, learning, and organizational abilities. Acetylcholinesterase is one of the well-established targets for managing this disease. However, the existing acetylcholines...

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Bibliographic Details
Main Authors: Ishtiaque Ahammad, Zeshan Mahmud Chowdhury, Arittra Bhattacharjee, Sheikh Sunzid Ahmed, Farzana Akter, Mohammad Uzzal Hossain, Keshob Chandra Das, Chaman Ara Keya, Md. Salimullah
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Alzheimer's
Dexketoprofen
Molecular dynamics simulation
ADMET
In silico
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914823002265

Internet

http://www.sciencedirect.com/science/article/pii/S2352914823002265

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