Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes

Abstract Genome-wide association studies suggest significant overlaps in Parkinson’s disease (PD) and schizophrenia (SZ) risks, but the underlying mechanisms remain elusive. The protein-protein interaction network (‘interactome’) plays a crucial role in PD and SZ and can incorporate their spatiotemp...

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Bibliographic Details
Main Authors: Kalyani B. Karunakaran, Sanjeev Jain, Samir K. Brahmachari, N. Balakrishnan, Madhavi K. Ganapathiraju
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-024-00439-3