Glucosylceramide modulates membrane traffic along the endocytic pathway

Glucosylceramide modulates membrane traffic along the endocytic pathway

Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the effects of storage. Gaucher disease is a heredita...

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Bibliographic Details
Main Authors: Dan J. Sillence, Vishwajeet Puri, David L. Marks, Terry D. Butters, Raymond A. Dwek, Richard E. Pagano, Frances M. Platt
Format: Article
Language:English
Published: Elsevier 2002-11-01
Series:Journal of Lipid Research
Subjects:
glycosphingolipid
Gaucher disease
Golgi
endocytic trafficking
sphingolipid sorting
BODIPY
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520327589

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http://www.sciencedirect.com/science/article/pii/S0022227520327589

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