Glucosylceramide modulates membrane traffic along the endocytic pathway

Glucosylceramide modulates membrane traffic along the endocytic pathway

Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the effects of storage. Gaucher disease is a heredita...

Full description

Bibliographic Details
Main Authors:	Dan J. Sillence, Vishwajeet Puri, David L. Marks, Terry D. Butters, Raymond A. Dwek, Richard E. Pagano, Frances M. Platt
Format:	Article
Language:	English
Published:	Elsevier 2002-11-01
Series:	Journal of Lipid Research
Subjects:	glycosphingolipid Gaucher disease Golgi endocytic trafficking sphingolipid sorting BODIPY
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520327589

Similar Items

Glucosylceramide modulates membrane traffic along the endocytic pathway.
by: Sillence, D, et al.
Published: (2002)

Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis
by: Natsuki Kita, et al.
Published: (2024-03-01)

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain
by: Scott D. Larsen, et al.
Published: (2012-02-01)

Protein Sorting in Plasmodium Falciparum
by: D.C. Ghislaine Mayer
Published: (2021-09-01)

The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis
by: Ludger Johannes
Published: (2021-05-01)

Assay for the transbilayer distribution of glycolipids: selective oxidation of glucosylceramide to glucuronylceramide by TEMPO nitroxyl radicals
by: Daniel J. Sillence, et al.
Published: (2000-08-01)

Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia[S]
by: Saša Štefanić, et al.
Published: (2010-09-01)

Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting
by: Qiang-Qiang Wang, et al.
Published: (2023-08-01)

Transcriptomic Analysis of Extracellular RNA Governed by the Endocytic Adaptor Protein Cin1 of Cryptococcus deneoformans
by: Muxing Liu, et al.
Published: (2020-06-01)

Editorial: Bioactive sphingolipids in health and disease
by: Mutay Aslan, et al.
Published: (2022-10-01)

Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks
by: Hongjie Guo, et al.
Published: (2024-03-01)

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
by: Megan M. Young, et al.
Published: (2016-11-01)

SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway
by: Lin Zhao, et al.
Published: (2021-12-01)

Involvement of a Cluster of Basic Amino Acids in Phosphorylation-Dependent Functional Repression of the Ceramide Transport Protein CERT
by: Asako Goto, et al.
Published: (2022-08-01)

Circulating Lipoprotein Sphingolipids in Chronic Kidney Disease with and without Diabetes
by: Maria F. Lopes-Virella, et al.
Published: (2024-01-01)

9-O Acetylated Gangliosides in Health and Disease
by: Luis Vicente Herrera-Marcos, et al.
Published: (2023-05-01)

Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mices⃞
by: Elias N. Glaros, et al.
Published: (2008-02-01)

A Targeted Mass Spectrometric Analysis Reveals the Presence of a Reduced but Dynamic Sphingolipid Metabolic Pathway in an Ancient Protozoan, Giardia lamblia
by: Trevor T. Duarte, et al.
Published: (2019-07-01)

Sphingolipids as Potential Therapeutic Targets against Enveloped Human RNA Viruses
by: Eric J. Yager, et al.
Published: (2019-10-01)

Sphingolipid-Based Synergistic Interactions to Enhance Chemosensitivity in Lung Cancer Cells
by: Susana Mesén-Porras, et al.
Published: (2023-11-01)

An Update on the Key Factors Required for Plant Golgi Structure Maintenance
by: Qingchen Rui, et al.
Published: (2022-06-01)

Effect of Glycosphingolipids on Osteoclastogenesis and Osteolytic Bone Diseases
by: Adel eErsek, et al.
Published: (2012-08-01)

Endocytic trafficking induces lateral root founder cell specification in Arabidopsis thaliana in a process distinct from the auxin-induced pathway
by: Stefanía Morales-Herrera, et al.
Published: (2023-01-01)

Quantification of glucosylceramide in plasma of Gaucher disease patients
by: Maria Viviane Gomes Muller, et al.
Published: (2010-12-01)

Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes
by: Miroslav Machala, et al.
Published: (2021-08-01)

The Role of Exosomes in Lysosomal Storage Disorders
by: Adenrele M. Gleason, et al.
Published: (2021-04-01)

Editorial: Golgi Dynamics in Physiological and Pathological Conditions
by: Kristian Prydz, et al.
Published: (2020-01-01)

β-Glycosphingolipids as Mediators of Both Inflammation and Immune Tolerance: A Manifestation of Randomness in Biological Systems
by: Yaron Ilan
Published: (2019-05-01)

Role of μ-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish
by: Lindsey T. Lelieveld, et al.
Published: (2019-11-01)

A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis
by: Brianna M. Quinville, et al.
Published: (2021-05-01)

Lipids as Targets for Renal Cell Carcinoma Therapy
by: Bisera Stepanovska Tanturovska, et al.
Published: (2023-02-01)

Critical Determinants in ER-Golgi Trafficking of Enzymes Involved in Glycosylation
by: Ning Zhang, et al.
Published: (2022-02-01)

pH Sensitive Dextran Coated Fluorescent Nanodiamonds as a Biomarker for HeLa Cells Endocytic Pathway and Increased Cellular Uptake
by: Linyan Nie, et al.
Published: (2021-07-01)

Small molecules targeting endocytic uptake and recycling pathways
by: Giampaolo Placidi, et al.
Published: (2023-03-01)

Endocytic Adaptors in Cardiovascular Disease
by: Kui Cui, et al.
Published: (2020-12-01)

Post-Golgi Trafficking and Transport of Cell Wall Components
by: Rosalie Sinclair, et al.
Published: (2018-12-01)

REGULATION OF Fc RECEPTOR ENDOCYTIC TRAFFICKING BY UBIQUITINATION
by: Rosa eMolfetta, et al.
Published: (2014-09-01)

Corrigendum: Small molecules targeting endocytic uptake and recycling pathways
by: Giampaolo Placidi, et al.
Published: (2023-08-01)

GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth
by: Meghana Nagaraj, et al.
Published: (2022-09-01)

Identification and Localization of the First Known Proteins of the Trypanosoma cruzi Cytostome Cytopharynx Endocytic Complex
by: Nathan Michael Chasen, et al.
Published: (2020-01-01)