Validation of metagenomic next-generation sequencing of bronchoalveolar lavage fluid for diagnosis of suspected pulmonary infections in patients with systemic autoimmune rheumatic diseases receiving immunosuppressant therapy

Validation of metagenomic next-generation sequencing of bronchoalveolar lavage fluid for diagnosis of suspected pulmonary infections in patients with systemic autoimmune rheumatic diseases receiving immunosuppressant therapy

BackgroundThe accuracy and sensitivity of conventional microbiological tests (CMTs) are insufficient to identify opportunistic pathogens in patients with systemic autoimmune rheumatic diseases (SARDs). The study aimed to assess the usefulness of metagenomic next-generation sequencing (mNGS) vs. CMTs...

Full description

Bibliographic Details
Main Authors: Sichun Wen, Siqi Peng, Xuejiao Hu, Nan Jiang, Bohou Li, Boxi Chen, Shuting Deng, Ye Yuan, Qiong Wu, Yiming Tao, Jianchao Ma, Sijia Li, Ting Lin, Feng Wen, Zhuo Li, Renwei Huang, Zhonglin Feng, Chaosheng He, Wenjian Wang, Xinling Liang, Wei Shi, Lixia Xu, Shuangxin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Medicine
Subjects:
metagenomic next-generation sequencing
systemic autoimmune rheumatic diseases
immunosuppressants
bronchoalveolar lavage fluid
pulmonary infection
antibiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1161661/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1161661/full

Similar Items