Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop

Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop

Abstract Background miR-133a-3p has been recently discovered to be down-regulated in various human malignancies, including breast cancer, and reduced miR-133a-3p levels have been significantly associated with breast cancer cell growth and invasion. However, the regulatory mechanisms leading to abnor...

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Bibliographic Details
Main Authors: Wanyue Shi, Tingting Tang, Xinping Li, Siwei Deng, Ruiyi Li, Yingshan Wang, Yifei Wang, Tiansong Xia, Yanfeng Zhang, Ke Zen, Liang Jin, Yi Pan
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
DNA methylation
miR-133a-3p
Breast cancer
Metastasis
MAML1
DNMT3A
Online Access:http://link.springer.com/article/10.1186/s13046-019-1400-z

Internet

http://link.springer.com/article/10.1186/s13046-019-1400-z

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