Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling

Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling

Trichodermin (TCD), a trichothecene first isolated from marine Trichoderma viride, is an inhibitor of eukaryotic protein synthesis. However, the potential effects of TCD on human oral squamous cell carcinoma (OSCC) cells and the underlying molecular mechanisms remain unknown. In this study, the expo...

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Bibliographic Details
Main Authors: Hsien-Lin Chen, Yi-Hao Lo, Chieh-Liang Lin, Tzong-Huei Lee, Wan Leung, Shih-Wei Wang, In-Pin Lin, Mei-Ying Lin, Chien-Hsing Lee
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Trichodermin
Oral squamous cell carcinoma
Migration
HDAC-2
Mitochondrial oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222007405

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http://www.sciencedirect.com/science/article/pii/S0753332222007405

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