Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to effi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22621-2 |