Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives
1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to effi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22621-2 |
| _version_ | 1818430812489515008 |
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| author | Peng-Ying Jiang Kai-Fang Fan Shaoyu Li Shao-Hua Xiang Bin Tan |
| author_facet | Peng-Ying Jiang Kai-Fang Fan Shaoyu Li Shao-Hua Xiang Bin Tan |
| author_sort | Peng-Ying Jiang |
| collection | DOAJ |
| description | 1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to efficiently access the QUINOL scaffolds in a metal-free manner. |
| first_indexed | 2024-12-14T15:39:22Z |
| format | Article |
| id | doaj.art-93f9dd3539eb426fb76788c1596d48ac |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:39:22Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-93f9dd3539eb426fb76788c1596d48ac2022-12-21T22:55:39ZengNature PortfolioNature Communications2041-17232021-04-011211910.1038/s41467-021-22621-2Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivativesPeng-Ying Jiang0Kai-Fang Fan1Shaoyu Li2Shao-Hua Xiang3Bin Tan4Department of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction between isoquinolines and 2-naphthols to efficiently access the QUINOL scaffolds in a metal-free manner.https://doi.org/10.1038/s41467-021-22621-2 |
| spellingShingle | Peng-Ying Jiang Kai-Fang Fan Shaoyu Li Shao-Hua Xiang Bin Tan Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives Nature Communications |
| title | Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives |
| title_full | Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives |
| title_fullStr | Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives |
| title_full_unstemmed | Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives |
| title_short | Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives |
| title_sort | metal free oxidative cross coupling enabled practical synthesis of atropisomeric quinol and its derivatives |
| url | https://doi.org/10.1038/s41467-021-22621-2 |
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