Folate regulates RNA m5C modification and translation in neural stem cells

Abstract Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels. Either deficiency or excess of folate may lead to neurologic...

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Bibliographic Details
Main Authors: Xiguang Xu, Zachary Johnson, Amanda Wang, Rachel L. Padget, James W. Smyth, Hehuang Xie
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-022-01467-0