Exploring the potential benefits of false discovery rates for region-based testing of association with rare genetic variation
When analyzing the data arising from exome or whole-genome sequencing studies, window-based tests, i.e. tests that jointly analyze all genetic data in a small genomic region, are very popular. However, power is known to be quite low for finding associations with phenotypes using these tests, and h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-01-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00011/full |