Microwave-Assisted Synthesis of Novel Pyrazolo[3,4-g][1,8]naphthyridin-5-amine with Potential Antifungal and Antitumor Activity

Microwave-Assisted Synthesis of Novel Pyrazolo[3,4-g][1,8]naphthyridin-5-amine with Potential Antifungal and Antitumor Activity

The microwave assisted reaction between heterocyclic o-aminonitriles 1 and cyclic ketones 2 catalyzed by zinc chloride led to new series of pyrazolo[3,4-b] [1,8]naphthyridin-5-amines 3 in good yields. This procedure provides several advantages such as being environmentally friendly, high yields, sim...

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Bibliographic Details
Main Authors: Paola Acosta, Estefanía Butassi, Braulio Insuasty, Alejandro Ortiz, Rodrigo Abonia, Susana A. Zacchino, Jairo Quiroga
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
antifungal activity
antitumoral activity
pyrazolonaphthyridines
microwave irradiation
Candida albicans
Cryptococcus neoformans
Online Access:http://www.mdpi.com/1420-3049/20/5/8499

Internet

http://www.mdpi.com/1420-3049/20/5/8499

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