Influence of homoarginine on creatine accumulation and biosynthesis in the mouse

Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively. AGAT also synthesizes homoarginine (hArg), low levels of which predict poor outcomes in human cardiovas...

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Bibliographic Details
Main Authors: Craig A. Lygate, Hannah A. Lake, Debra J. McAndrew, Stefan Neubauer, Sevasti Zervou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Nutrition
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.969702/full