Influence of homoarginine on creatine accumulation and biosynthesis in the mouse

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse

Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively. AGAT also synthesizes homoarginine (hArg), low levels of which predict poor outcomes in human cardiovas...

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Bibliographic Details
Main Authors: Craig A. Lygate, Hannah A. Lake, Debra J. McAndrew, Stefan Neubauer, Sevasti Zervou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Nutrition
Subjects:
creatine
homoarginine
L-arginine:glycine amidinotransferase (AGAT)
guanidinoacetate N-methyltransferase (GAMT)
creatine transporter
pancreas
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.969702/full

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https://www.frontiersin.org/articles/10.3389/fnut.2022.969702/full

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