DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomas

DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomas

No clinical assay currently exists to classify glioma tumours based on gene expression. Here, the authors develop a DNA methylation-based classifier, Unified Diagnostic Pipeline (UniD) that identifies genomic alterations and gene expression subtypes of gliomas.

Bibliographic Details
Main Authors: Jie Yang, Qianghu Wang, Ze-Yan Zhang, Lihong Long, Ravesanker Ezhilarasan, Jerome M. Karp, Aristotelis Tsirigos, Matija Snuderl, Benedikt Wiestler, Wolfgang Wick, Yinsen Miao, Jason T. Huse, Erik P. Sulman
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31827-x

Internet

https://doi.org/10.1038/s41467-022-31827-x

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