Rivaroxaban Modulates TLR4/Myd88/NF-Kβ Signaling Pathway in a Dose-Dependent Manner With Suppression of Oxidative Stress and Inflammation in an Experimental Model of Depression

Rivaroxaban Modulates TLR4/Myd88/NF-Kβ Signaling Pathway in a Dose-Dependent Manner With Suppression of Oxidative Stress and Inflammation in an Experimental Model of Depression

Depression is a common mental illness leading to upset or anxiety, with a high incidence rate in the world. Depression can lead to suicidal thoughts and behavior. The present study aimed to evaluate the effect of the direct oral anticoagulant rivaroxaban (RVX), in the model of depression induced by...

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Bibliographic Details
Main Authors: Walaa Yehia Abdelzaher, Hanaa H. Mohammed, Nermeen N. Welson, Gaber El-Saber Batiha, Roua S. Baty, Asmaa Mohamed Abdel-Aziz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
depression
MyD88
NF-kβ
rivaroxban
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.715354/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.715354/full

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