l-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain

l-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain

Dysregulation of dopamine receptors (DARs) is believed to contribute to Parkinson disease (PD) pathology. G protein-coupled receptors (GPCR) undergo desensitization via activation-dependent phosphorylation by G protein-coupled receptor kinases (GRKs) followed by arrestin binding. Using quantitative...

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Bibliographic Details
Main Authors: E. Bezard, C.E. Gross, Li Qin, V.V. Gurevich, J.L. Benovic, E.V. Gurevich
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neurobiology of Disease
Subjects:
Arrestin
G protein-coupled receptor kinase
Dyskinesia
Parkinson disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002402

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http://www.sciencedirect.com/science/article/pii/S0969996104002402

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