A bimolecular modification strategy for developing long-lasting bone anabolic aptamer

A bimolecular modification strategy for developing long-lasting bone anabolic aptamer

The molecular weight of nucleic acid aptamers (20 kDa) is lower than the cutoff threshold of the renal filtration (30–50 kDa), resulting in a very short half-life, which dramatically limits their druggability. To address this, we utilized 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(4-hydroxy-2-oxo-2...

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Bibliographic Details
Main Authors: Huarui Zhang, Sifan Yu, Shuaijian Ni, Amu Gubu, Yuan Ma, Yihao Zhang, Haitian Li, Yuzhe Wang, Luyao Wang, Zongkang Zhang, Yuanyuan Yu, Aiping Lyu, Baoting Zhang, Ge Zhang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
aptamers
long-lasting modification
sclerostin
osteogenesis imperfecta
low-molecular-weight coupling agents
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002913

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http://www.sciencedirect.com/science/article/pii/S2162253123002913

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