Tumor Necrosis Factor-α (TNFα) Stimulates Triple-Negative Breast Cancer Stem Cells to Promote Intratumoral Invasion and Neovasculogenesis in the Liver of a Xenograft Model

Tumor Necrosis Factor-α (TNFα) Stimulates Triple-Negative Breast Cancer Stem Cells to Promote Intratumoral Invasion and Neovasculogenesis in the Liver of a Xenograft Model

TNBC represents the most aggressive breast cancer subtype. Although cancer stem cells (CSCs) are a minor fraction of all cancer cells, they are highly cancerous when compared to their non-stem counterparts, playing a major role in tumor recurrence and metastasis. Angiogenic stimuli and the tumor env...

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Bibliographic Details
Main Authors: Harini Narasimhan, Francesca Ferraro, Andreas Bleilevens, Ralf Weiskirchen, Elmar Stickeler, Jochen Maurer
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biology
Subjects:
triple-negative breast cancer
cancer stem cells
TNFα
EMT
seed-and-soil theory
Online Access:https://www.mdpi.com/2079-7737/11/10/1481

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