Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity

Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity

The anti-tumour immune response greatly depends on the number of tumour neoantigens. Here the authors show in mouse models that a therapeutic strategy aimed at increasing the number of neoantigens via downregulating TAP, an antigen processing associated protein, enhances anti-tumour immunity and the...

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Bibliographic Details
Main Authors: Greta Garrido, Brett Schrand, Ailem Rabasa, Agata Levay, Francesca D’Eramo, Alexey Berezhnoy, Shrey Modi, Tal Gefen, Koen Marijt, Elien Doorduijn, Vikas Dudeja, Thorbald van Hall, Eli Gilboa
Format: Article
Language:English
Published: Nature Portfolio 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11728-2

Internet

https://doi.org/10.1038/s41467-019-11728-2

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