HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma

HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma

The neural crest transcription factor BRN3A is essential for the proliferation and survival of melanoma cells. It is frequently expressed in melanoma but not in normal melanocytes or benign nevi. The mechanisms underlying the aberrant expression of BRN3A are unknown. Here, we investigated the epigen...

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Bibliographic Details
Main Authors: Markus V. Heppt, Anja Wessely, Eva Hornig, Claudia Kammerbauer, Saskia A. Graf, Robert Besch, Lars E. French, Alexander Matthies, Silke Kuphal, Melanie Kappelmann-Fenzl, Anja K. Bosserhoff, Carola Berking
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
epigenetic regulation
BRN3A
HDAC
HAT
DNA methylation
Online Access:https://www.mdpi.com/1422-0067/23/2/849

Internet

https://www.mdpi.com/1422-0067/23/2/849

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