The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions

The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions

ABSTRACTApicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have major health and economic burdens. These unicellular pathogens are obligate intracellular parasites that heavily depend on lipid metabolism for the survival within their hosts. Their lipid synthesis relies...

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Bibliographic Details
Main Authors: Sarah Charital, Serena Shunmugam, Sheena Dass, Anna Maria Alazzi, Christophe-Sébastien Arnold, Nicholas J. Katris, Samuel Duley, Nyamekye A. Quansah, Fabien Pierrel, Jérôme Govin, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
Toxoplasma gondii
lipid
fatty acid
acylCoA synthetase
lipidomics
fatty acid metabolism
Online Access:https://journals.asm.org/doi/10.1128/mbio.00427-24

Internet

https://journals.asm.org/doi/10.1128/mbio.00427-24

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