Modified 5-aminolevulinic acid photodynamic therapy suppresses cutaneous squamous cell carcinoma through blocking Akt/mTOR-mediated autophagic flux

Modified 5-aminolevulinic acid photodynamic therapy suppresses cutaneous squamous cell carcinoma through blocking Akt/mTOR-mediated autophagic flux

Background: We previously found that modified 5-aminolevulinic acid photodynamic therapy (M-PDT) is painless and effective in cutaneous squamous cell carcinoma (cSCC) treatment, however, the regulatory mechanism of M-PDT in cSCC is still unclear.Objective: To clarify the effect and relevant regulato...

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Bibliographic Details
Main Authors: Qingyu Zeng, Jia Liu, Yu Yan, Guolong Zhang, Periru Wang, Haiyan Zhang, Xiaojing Liu, Linglin Zhang, Xiuli Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
M-PDT
cSCC
autophagic flux
ROS
AKT/mTOR signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1114678/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1114678/full

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