CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes

CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes

The common gamma chain (γc) contributes to the formation of different cytokine receptors [e.g., IL-2 receptor (IL-2R), IL-7R, and IL-15R], which are important for generation of self-reactive T-cells in autoimmune diseases, like in type 1 diabetes (T1D). Whereas, the roles of membrane and soluble IL-...

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Bibliographic Details
Main Authors: Julia Seyfarth, Nathalie Mütze, Jennifer Antony Cruz, Sebastian Kummer, Christina Reinauer, Ertan Mayatepek, Thomas Meissner, Marc Jacobsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
biomarker
immunology
common gamma chain
interleukin-2
interleukin-7
type 1 diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00820/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00820/full

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