Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes

Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes

The bromodomain and extra-terminal domain proteins (BETs) family serve as epigenetic “readers”, which recognize the acetylated histones and recruit transcriptional regulator complexes to chromatin, eventually regulating gene transcription. Accumulating evidences demonstrate that pan BET inhibitors (...

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Bibliographic Details
Main Authors: Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
bromodomain containing protein 2 (BRD2)
bromodomain and extra-terminal domain (BET) family
cardiac hypertrophy
cardiac metabolism
citrate cycle (TCA cycle)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.887991/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.887991/full

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