Subinhibitory concentrations of Honokiol reduce α-Hemolysin (Hla) secretion by Staphylococcus aureus and the Hla-induced inflammatory response by inactivating the NLRP3 inflammasome

Subinhibitory concentrations of Honokiol reduce α-Hemolysin (Hla) secretion by Staphylococcus aureus and the Hla-induced inflammatory response by inactivating the NLRP3 inflammasome

ABSTRACTStaphylococcus aureus (S. aureus) is one of the most serious human pathogens. α-Hemolysin (Hla) secreted by S. aureus is a key toxin for various infections. We herein report that Honokiol, a natural plant polyphenol, inhibits the secretion and hemolytic activity of staphylococcal Hla with co...

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Bibliographic Details
Main Authors: Na Guo, Zuojia Liu, Zhiqiang Yan, Zonghui Liu, Kun Hao, Chuanbo Liu, Jin Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Staphylococcus aureus
α-Hemolysin
Honokiol
inflammasome
binding interaction
molecular docking
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1617643

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2019.1617643

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