Concomitant TP53 mutation in early-stage resected EGFR-mutated non-small cell lung cancer: a narrative approach in a genetically admixed Brazilian cohort

Concomitant TP53 mutation in early-stage resected EGFR-mutated non-small cell lung cancer: a narrative approach in a genetically admixed Brazilian cohort

TP53 mutations are frequent in non-small cell lung cancer (NSCLC) and have been associated with poor outcome. The prognostic and predictive relevance of EGFR/TP53 co-mutations in NSCLC is controversial. We analyzed lung tissue specimens from 70 patients with NSCLC using next-generation sequencing to...

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Bibliographic Details
Main Authors: J. Machado-Rugolo, C.M. Baldavira, T.G. Prieto, E.H.R. Olivieri, A.T. Fabro, C.A. Rainho, E.C. Castelli, P.E.M. Ribolla, A.M. Ab'Saber, T. Takagaki, M.A. Nagai, V.L. Capelozzi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2023-04-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Non-small-cell lung cancer (NSCLC)
Epidermal growth factor receptor (EGFR)
Tumor protein 53 (TP53)
Mutation
Survival
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100626&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100626&tlng=en

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