Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition
Emopamil-Binding Protein (EBP), is an endoplasmic reticulum membrane protein involved in cholesterol biosynthesis, autophagy and oligodendrocyte formation. Here, authors report two crystal structures of human EBP and identify a pharmacological binding site that accommodates multiple different ligand...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10279-w |