Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

ABSTRACT We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a combination of purchase and chemical...

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Bibliographic Details
Main Authors: Shilah Bonnett, Jo-Ann Jee, Somsundaram Chettiar, Yulia Ovechkina, Aaron Korkegian, Eric Greve, Joshua Odingo, Tanya Parish
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
antitubercular
drug discovery
antibiotic
protein secretion
bactericidal activity
tuberculosis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04974-22

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https://journals.asm.org/doi/10.1128/spectrum.04974-22

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