Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.

Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.

BACKGROUND: Interleukin-8 (IL-8, CXCL8) is readily produced by human malignant cells. Dendritic cells (DC) both produce IL-8 and express the IL-8 functional receptors CXCR1 and CXCR2. Most human colon carcinomas produce IL-8. IL-8 importance in malignancies has been ascribed to angiogenesis promotio...

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Bibliographic Details
Main Authors: Carlos Alfaro, Natalia Suárez, Ivan Martínez-Forero, Asís Palazón, Ana Rouzaut, Sarai Solano, Esperanza Feijoo, Alfonso Gúrpide, Elixabet Bolaños, Lorena Erro, Juan Dubrot, Sandra Hervás-Stubbs, Alvaro Gonzalez, Jose Luis Perez-Gracia, Ignacio Melero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3056721?pdf=render

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http://europepmc.org/articles/PMC3056721?pdf=render

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