No Association between Single-Nucleotide Polymorphisms of The S1PR1 Gene or Interleukin-17 Levels with Fingolimod Response in A Small Group of Iranian Relapsing-Remitting Multiple Sclerosis Patients: A Case-Control Study

No Association between Single-Nucleotide Polymorphisms of The S1PR1 Gene or Interleukin-17 Levels with Fingolimod Response in A Small Group of Iranian Relapsing-Remitting Multiple Sclerosis Patients: A Case-Control Study

Objective: Multiple sclerosis (MS) has a multi-factorial etiology involving genetic factors. Fingolimod (Gilenya ®,FTY720) modulates the G-protein-coupled sphingosine 1-phosphate (S1P) receptors, S1PR1, 2, 3, 4 and 5. Variationin the human S1PR1 coding sequence results in heterogeneity in the functi...

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Bibliographic Details
Main Authors: Nasrin Moheghi, Payam Sasannezhad, Andrew John Walley
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2024-03-01
Series:Cell Journal
Subjects:
fingolimod
interleukin-17
multiple sclerosis
polymorphism
sphingosine 1-phosphate receptor
Online Access:https://www.celljournal.org/article_711247_4c6fdd2bdb75181aa3ed10ff0ce774ad.pdf

Internet

https://www.celljournal.org/article_711247_4c6fdd2bdb75181aa3ed10ff0ce774ad.pdf

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